Clinical distribution,infection characteristics and drug resistance analysis of Burkholderia in Linyi area from 2013 to 2023
Objective This study analyzed the clinical distribution,infection characteristics,and drug resistance of Burkholderia detected in the Linyi area from 2013 to 2023 and to provide references for anti-infective treatment of Burkholderia.Methods The data on Burkholderia isolated and identified from three hospitals in the Linyi area from 2013 to 2023 were analyzed retrospectively,along with the patient data.Results A total of 414 strains of Burkholderia were isolated,of which 373 were identified as Burkholderia cepacian,with an isolation rate of 90.10％.It was mainly isolated from the intensive care unit(ICU)and respiratory department and accounted for the highest proportion of sputum samples(311 strains,75.12％).The infection caused by Burkholderia was associated with patients'age,underlying diseases,invasive procedures,and use of broad-spectrum antibiotics.Most patients with the Burkholderia infection were over 60 years old(53.67％,212/395).The proportion of type 2 diabetes in patients with other Burkholderia infections was higher than that in patients with Burkholderia cepacia infections,and the difference was statistically significant(x2=11.120,P=0.001).The resistance rates of Burkholderia cepacia to trimethoprim-sulfamethoxazole,ceftazidime,levofloxacin,and minocycline remained unstable over the past decade,but the resistance rate was low.The resistance rate to meropenem showed an increasing trend in the past 3 years.The resistance rate of Burkholderia cepacia to ticacillin/clavulanic acid was high.Resistance to ceftazidime,ticacillin/clavulanate and meropenem varied significantly among different Burkholderella species.Conclusion The Burkholderia detected in the Linyi area during 2013-2023 mainly came from ICU,mainly sputum samples,and the most vulnerable population were people over the age of 60.Type 2 diabetes was one of the risk factors for other Burkholderia infections.The resistance rate of Burkholderia to antibiotics commonly used varied,and clinicians could preferentially select antibiotics with a low resistance rate according to the results of drug sensitivity.
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