MmpL(Mycobacterial membrane protein large,MmpL)蛋白是结核分枝杆菌的一类重要外排泵转运蛋白,主要参与底物转运,也能介导耐药发生,是潜在的抗结核靶点.本文从MmpL蛋白的结构与功能、耐药机制、蛋白抑制剂等方面进行综述,旨在为MmpL蛋白的功能研究及分枝杆菌的新药研发提供参考建议.
Review on function and inhibitor of mycobacterial MmpL proteins
Mycobacterial membrane protein large(MmpL)is an important type of efflux pump transporter in Mycobacterium tuberculosis that involves substrate transport and antibiotic resistance,thus being a potential target for anti-tuberculosis.The structure,function,antibiotic resistance and inhibitors of the MmpL proteins were reviewed with the purpose of providing suggestions for exploration of MmpL function and the development of new anti-mycobacteria agents.
NETL
NSTL
万方数据
