MmpL蛋白功能及其抑制剂研究进展
Review on function and inhibitor of mycobacterial MmpL proteins
崔嘉伟 1豆梁丁 1赵西林 1王岱1
作者信息
- 1. 厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门 361102
- 折叠
摘要
MmpL(Mycobacterial membrane protein large,MmpL)蛋白是结核分枝杆菌的一类重要外排泵转运蛋白,主要参与底物转运,也能介导耐药发生,是潜在的抗结核靶点.本文从MmpL蛋白的结构与功能、耐药机制、蛋白抑制剂等方面进行综述,旨在为MmpL蛋白的功能研究及分枝杆菌的新药研发提供参考建议.
Abstract
Mycobacterial membrane protein large(MmpL)is an important type of efflux pump transporter in Mycobacterium tuberculosis that involves substrate transport and antibiotic resistance,thus being a potential target for anti-tuberculosis.The structure,function,antibiotic resistance and inhibitors of the MmpL proteins were reviewed with the purpose of providing suggestions for exploration of MmpL function and the development of new anti-mycobacteria agents.
关键词
分枝杆菌/MmpL蛋白/耐药机制/蛋白抑制剂Key words
Mycobacterium tuberculosis/MmpL protein/Antibiotic resistance/Protein inhibitor引用本文复制引用
基金项目
深圳市科技研发资金(JCYJ20220530143409021)
出版年
2024
NETL
NSTL
万方数据