革兰阴性菌对头孢地尔耐药机制的研究进展
Advances in the resistance mechanisms to cefiderocol in Gram-negative bacteria
吴文琦 1李家扬 2田赛 3吴秀文 1任建安1
作者信息
- 1. 南京大学医学院附属金陵医院,南京 210002
- 2. 东南大学医学院,南京 210009
- 3. 南京中医药大学,南京 210023
- 折叠
摘要
头孢地尔是一种新型头孢菌素,体外抗菌活性高,在临床疗效和安全性上均有不错表现,对临床常见的碳青霉烯酶稳定,可模拟铁载体进入细菌周质间隙,因此几乎不受膜孔蛋白和外排泵的影响,但也促使细菌进化出各式各样的耐药机制.本文梳理了常见革兰阴性菌对头孢地尔的耐药机制,归纳总结各类细菌的耐药特点,深入探讨头孢地尔耐药的各方面因素,以期为临床应用和相关研究提供参考.
Abstract
Cefiderocol is a novel cephalosporin with high antibacterial activity in vitro and good performance in clinical efficacy and safety.It is stable for common carbapenemase and can simulate siderophore entering the bacterial periplasmic space,which is almost unaffected by porin proteins and efflux pumps.However,this unique mechanism has also led to the evolution of various resistance mechanisms among bacteria.This review sorted out the resistance mechanisms of common Gram-negative bacteria against cefiderocol,summarized the characteristics of antibiotic resistance in different bacteria,and in-depth analyzed multiple elements of resistance to cefiderocol in hopes of providing a reference for its clinical application and related research.
关键词
头孢地尔/碳青霉烯酶/铁载体/耐药Key words
Cefiderocol/Carbapenemase/Siderophore/Antibiotic resistance引用本文复制引用
基金项目
江苏省重点研发计划(BE2022823)
江苏省医学创新中心(CXZX202217)
出版年
2024
NETL
NSTL
万方数据