A review on the association between chlorhexidine and antibiotic resistance
Antibiotic resistance is a global public health crisis affecting human beings that enormously threatens lives and burdens society and the economy.Chlorhexidine(CHX)is one of the most widely applied antiseptic agents in clinical practice.Currently,growing research has revealed a close association between CHX and antibiotic resistance.On the one hand,it has been demonstrated that CHX could induce antibiotic cross-resistance,even including resistance to the last-sort antibiotic in several important pathogens causing nosocomial infections.On the other hand,the co-resistance between CHX and antibiotics might exist.The overexpression of efflux pumps and alterations of cell membranes are vital mechanisms accounting for the association between CHX and antibiotic resistance.However,the potential risk of the extensive utilization of CHX in clinical practice has been far underestimated.Thus,this paper reviewed the evidence on the association between CHX and antibiotic resistance and linking mechanisms to raise awareness of its clinical application.
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