Distribution and antibiotic resistance of clinical isolates from blood culture in Gansu Province from 2020 to 2022
Objective To analyze the population distribution of bacteria from blood culture and the antibiotic resistance profile among children,adults and elderly patients in Gansu Province.Methods WHONET 5.6 software was used to investigate the distribution and antimicrobial susceptibility of bacteria isolated from blood cultures of qualified hospitals in the Gansu antimicrobial susceptibility surveillance system from January 2020 to December 2022,and the results were determined according to CLSI M100 2022.Results A total of 12818 non-repeated isolates were collected from 2020 to 2022,of which Gram-positive bacteria and Gram-negative bacteria account for 40.4％and 59.6％,respectively.The isolates from children,adults and elderly patients accounted for 14.2％,51.5％and 34.3％.The prevalence of MRSA in S.aureus and MRCNS in coagulase-negative Staphylococcus was 35.5％and 71.7％,respectively.The percentage of MRSA in children was significantly lower than that in adults and elderly patients;they account for 22.2％,38.1％and 38.3％,respectively.Only vancomycin,teicoraline and linezolid-resistant strains were not detected in the CNS or S.aureus.The resistance of E.faecium to most of the tested antibiotics was higher than that of E.faecalis,apart from vancomycin,teicolanin and linezolid.No Streptococcus pneumonia strains were found resistant to penicillin G,vancomycin and linezolid.The resistance of Escherichia coli,Klebsiella pneumoniae,Serratia marcescens and Enterobacter to carbapenems ranged from 0.2％～0.4％,5.2％～6.0％,7.6％～8.1％and 3.2％～11.0％.The resistance of Escherichia coli in adults and elderly patients to 1/2 of tested antibiotics and 1/3 of tested antibiotics was higher than that in children,respectively.However,the resistance of Klebsiella pneumoniae in adults and elderly patients to 2/3 tested antibiotics was lower than that in children(P＜0.05).The resistance of Pseudomonas aeruginosa and Acinetobacter baumannii to carbapenems ranged from 12.2％to 15.1％and from 68.5％to 68.8％,respectively.Conclusion From 2020 to 2022,the resistance of clinical isolates from blood culture in Gansu province was still severe,and there were differences in the detection rate and drug resistance of isolates in different age groups,especially Gram-negative bacteria,between children and non-child patients.
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