Composition of pathogen spectrum and drug susceptibility analysis of pus infections in different populations in Shandong Province from 2017 to 2022
Objective To study the composition of pathogenic spectrum and drug resistance and susceptibility of pus samples from the patients of different ages in the Shandong area to provided a reference for early clinical empirical antimicrobial treatment for surgeons.Methods Clinical information and drug sensitivity results of isolates from pus samples reported by Shandong Province Pediatric Antimicrobial Resistance Surveillance System(SPARSS)members were retrospectively analyzed from 2017 to 2022.Results A total of 64302 strains of pathogenic bacteria were isolated.The bacteria isolated from neonatal pus were mainly Gram-positive bacteria,and the bacteria isolated from children's and adults'pus were mainly Gram-negative bacteria.In terms of age stratified distribution,Staphylococcus aureus was the most common pathogen isolated from the neonatal group,and Escherichia coli was the most common pathogen isolated from the pus of the children and adult group.The distribution of the bacteria was significantly different among the three groups(x2=245.5,P＜0.0001).The drug resistance rates of E.coli and Klebsiella pneumoniae were more serious in Enterobacteriaceae;the extended spectrum β-lactamases(ESBLs)and carbapenem-resistant E.coli accounted for 41.8％and 0.83％,respectively;K.pneumoniae accounted for 14.1％and 1.14％,respectively.The resistance rate of Pseudomonas aeruginosa to most antibiotics in adults was significantly higher than that in children.The detection rate of methicillin-resistant Staphylococcus aureus(MRSA)in Staphylococcus Spp.was 22.6％and decreased from 2017 to 2022,and the proportion of MRSA in newborns was significantly higher than that in children and adults(x2=12.32,P=0.0021).Conclusion The main pathogens of pus infection were E.coli,S.aureus,K.pneumoniae and P.aeruginosa,and the pathogen spectrum composition of different age groups was quite different,and the resistance rate of the main isolates was relatively high.Therefore,it is necessary to regularly monitor the pathogen spectrum of pus sources and the change rule of drug resistance in order to improve the accurate diagnosis and treatment of infectious diseases by surgeons.
Pus infectionPathogenic bacteriaDrug resistance rateNeonatesChildrenAdults
万方数据
