首页|2017-2022年山东地区不同人群中段尿分离菌的构成及药敏分析

2017-2022年山东地区不同人群中段尿分离菌的构成及药敏分析

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目的 了解山东地区中段尿标本分离菌的构成和耐药性及患者年龄差异,为临床早期经验性尿路感染抗菌药物选择提供参考依据.方法 利用WHONET5.6分析软件,回顾分析山东地区2017-2022年间山东省儿童组细菌耐药监测研究协作网成员单位上报的中段尿标本分离菌的构成及主要分离菌的药敏结果.结果 共分离143955株菌株,分离的细菌以革兰阴性菌为主,真菌以白念珠菌为主.对年龄分层分析发现,儿童组与成人组的菌种分布差异较大,有统计学意义(x2=509.4,P<0.0001).儿童组分离前两位的分离菌是大肠埃希菌、屎肠球菌,而成人组分离前两位的分离菌是大肠埃希菌和肺炎克雷伯菌;不论儿童组还是成人组,女性的细菌分离率均较男性高.碳青霉烯类耐药的大肠埃希菌和肺炎克雷伯菌的占比分别为1.7%和5.7%,对大部分受试抗菌药物儿童组菌株的耐药率高于成人组.结论 山东地区不同人群中段尿分离菌菌种分布不同,且不同分离菌对各种抗菌药物耐药性存在较大差异,因此对不同人群进行分离菌的分布和耐药性监测,对提高尿路感染的精准诊治水平和指导临床合理用药具有重要指导意义.
Composition of isolated strain and drug susceptibility analysis of midstream urine infection in different populations in Shandong Province from 2017 to 2022
Objective This study understood the composition of the isolated strain,drug resistance,and age difference of middle urine samples in Shandong Province,and provide a reference for the selection of antibacterial agents based on early clinical experience with urinary tract infection.Methods WHONET5.6 analysis software was used to retrospectively analyze the isolated strain of midstream urine samples reported by members of the Shandong Province Pediatric Antimicrobial Resistance Surveillance System(SPARSS)network in Shandong from 2017 to 2022 and the results of drug susceptibility to the main pathogens.Results A total of 143955 isolates were isolated.Gram-negative bacteria and Candida albicans were the main isolates.Age stratified analysis showed that the distribution of bacteria in the children group and the adults group was significantly different(x2=509.4,P<0.0001).The top two pathogens isolated from the children's group were Escherichia coli and Enterococcus faecium,while the top two pathogens isolated from the adults'group were E.coli and Klebsiella pneumoniae.In both children's and adults'groups,the bacterial isolation rate in women was higher than that in men.The drug resistance rates of carbapenem-resistant E.coli and K.pneumoniae accounted for 1.7%and 5.7%,respectively.The drug resistance rates of the most tested antibacterial strains in the children's group were higher than those in the adults'group.Conclusion The distribution of isolated bacteria in midstream urine in different populations in Shandong Province was different,and different isolates had great differences in drug resistance to various antibiotics.Therefore,monitoring the distribution and drug resistance of isolated bacteria in different populations is very important to improve the level of diagnosis and treatment and guide clinically rational drug use.

Isolated strainDrug resistanceUrinary tract infectionAdultsChildren

寇琳娜、张春艳、王梦园、纪冰、满思金、伊茂礼、李仁哲、王世富

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山东大学附属儿童医院临床微生物科,山东省儿童健康与疾病临床医学研究中心,济南 250022

山东省儿童微生物组学研究中心儿童细菌&真菌耐药监测研究协作网,济南 250022

滨州医学院附属医院检验科,滨州 256603

滕州市中心人民医院检验科,滕州 277500

烟台毓璜顶医院检验科,烟台 264000

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分离菌 耐药率 尿路感染 成人 儿童

国家科技重大专项山东省儿童健康与疾病临床医学研究中心项目济南卫生健康委员会科技计划济南卫生健康委员会科技计划

2017ZX10103004-007RC0062022-1-452022-2-149

2024

中国抗生素杂志
中国医药集团总公司四川抗菌素工业研究所,中国医学科学院医药生物技术研究所

中国抗生素杂志

CSTPCD北大核心
影响因子:1.08
ISSN:1001-8689
年,卷(期):2024.49(8)