Composition of the pathogen spectrum and drug susceptibility analysis of joint fluid infections in different populations in Shandong Province,from 2017 to 2022
Objective To understand the composition of the pathogen spectrum and drug resistance of joint fluid samples from different populations and different years in Shandong Province and to provide reference for early clinical empirical treatment.Methods The WHONET 5.6 analysis software was used to retrospectively analyze the pathogen composition and drug susceptibility of 1,243 joint fluid samples reported by SPARSS network members in Shandong Province from 2017 to 2022.Results The main isolates in joint fluid were Escherichia coli(42.1％)and Staphylococcus aureus(19.1％).The composition ratio of male to female strains was 59:41.The composition of strains increased in different years,and 360 strains were isolated in 2019,the largest number in the past year.The bacteria isolated from the joint fluid of the children group and the young and middle-aged group were mainly gram-negative bacteria,and the bacteria isolated from the joint fluid of the elderly group were mainly Gram-positive bacteria.There were significant differences in the distribution of Gram-positive and Gram-negative bacteria in the children group,the young and middle-aged group,and the adult group(x2=42.84,P＜0.0001).The proportion of ESBLs in Enterobacteriaceae was 49.8％,and the carbapenem-resistant E.coli was 1.0％.The rate of methicillin-resistant S.aureus was 29.8％.Conclusion The distribution of pathogenic bacteria in joint fluid varied among different populations and different years in Shandong Province,and there were great differences in the drug resistance of different pathogens to various antibiotics.Therefore,monitoring the distribution and drug resistance of pathogenic bacteria in different populations is very important to improve the diagnosis and treatment level of joint infections and guide clinically rational drug use.
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