Objective To evaluate the impact of blood sample quality assessment with the participation of pharmacists on the interpretation of vancomycin(VAN)plasma concentration.Methods A retrospective data on the patients treated with VAN and monitored on their plasma concentration was collected in Wuhan No.1 hospital from January to December,2022.The observation indexes,such as distribution type and proportion of unqualified samples,department distribution,difference between the before and the after of the re-evaluation of unqualified samples,and VAN plasma concentration distribution,were investigated.Results The study involved 92 patients and 177 samples from 20 related departments,with a total of 162 samples entering the VAN plasma concentration monitoring process.The proportion of qualified samples within the therapeutic concentration window of 10～20 mg/L was about 36.42％(59/162),being 22.84％(37/162)below 10 mg/L,and 30.86％(50/162)over 20 mg/L.The qualified samples were altogether 115(64.97％).The total unqualified samples were 62(35.03％),of which 15 were from the initial evaluation and 47 were from the re-evaluation.The unqualified samples from the re-evaluation were retested after standardized propaganda and education.The total 44 of samples indicated a significant concentration difference between the before and after of the retesting(P＜0.05),wherein,the samples from blood collection after administration exhibited the largest difference value(about-16.5 mg/L).Conclusion Under the sample-centered management mode,a significant improvement on the reliability of VAN TDM data has been achieved through reasonable evaluation in the pre-and post-analytical process,thus indicating a clinical application.
关键词
标本评估/万古霉素/以标本为中心/血药浓度解读/个体化药学服务
Key words
Sample evaluation/Vancomycin/Sample-centered/Interpretation of plasma vancomycin concentration/Individualizing pharmaceutical care
维普
万方数据