Objective To investigate the in vitro antimicrobial effects of cefazolin sodium for injection against staphylococci and provide reference for clinical medication.Methods Comparison of in vitro antimicrobial efficacy of localized and original cefazolin sodium by in vitro antibacterial susceptibility test,time-kill curve and pharmacokinetics/pharmacodynamics modeling was processed.Results The minimum inhibitory concentration(MIC)values of localized and original cefazolin sodium against staphylococci were consistent,with 0.25 μg/mL against Staphylococcus aureus(S.aureus)ATCC29213 and 2 clinical strains of methicillin-sensitive S.aureus(MSSA),and 0.06 μg/mL against 1 strain of methicillin-sensitive coagulase-negative Staphylococcus(MSCNS).There was no significant difference in the time-kill curve of the 2 types of cefazolin sodium against the 4 strains of S.aureus at 3 drug concentrations.Bacteria was significantly inhibited at the drug concentration of lxMIC,and the total number of colonies of 4 strains increased by less than 2 lgCFU/mL in 24 h.The number of colonies gradually decreased from 6 lgCFU/mL to about 3 lgCFU/mL at the 2xMIC and 4xMIC drug concentrations.Overall,the PK/PD results of the 2 agents were similar by analyzing the dynamic sterilization curves,but the area difference of the bactericidal curves of localized cefazolin sodium against MSCNS 117933 and MSSA164342 were greater than those of the original cefazolin sodium.The parameter values of the original cefazolin sodium were(151.40±0.05)and(177.69±2.79)lgCFU·h/mL,and the localized cefazolin sodium were(151.10±0.11)and(170.4±1.96)lgCFU·h/mL,respectively.Conclusion The antibacterial effect of localized cefazolin sodium against staphylococci is the same as that of original cefazolin sodium.
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