Research progress on the optrA gene mediating linezolid resistance in enterococci
Enterococcus is one of the common pathogens causing urinary tract infections,endocarditis,and hospital-associated infections.Linezolid is considered to be the last line of treatment for serious infections caused by multidrug-resistant Gram-positive bacteria.However,since the introduction of linezolid into clinical application,the emergence of linezolidin-resistant Enterococcus(LRE)has been reported continuously,which has become a major challenge to clinical treatment and public health.The acquisition of the transferrable oxazolidinone resistance gene optrA is an important resistance mechanism leading to LRE.The spread and prevalence of optrA in enterococci weakened the efficacy of linezolid in the treatment of clinically resistant strains,and great attention should be paid to its clinical application.This article reviewed the prevalence of LRE strains carrying the optrA gene,the mobile genetic elements involved in the transmission of the optrA gene,and the variants of the optrA gene,so as to provide a theoretical and scientific basis for clinical control of the prevalence of LRE and rational selection of antibiotics.
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