Pathogenic bacteria distribution and drug resistance of ICU patients in a grade A tertiary hospital from 2017 to 2023
Objective To investigate the infection status and clinical distribution characteristics of pathogens in patients hospitalized in the intensive care unit(ICU).Methods The bacterial infection of hospitalized ICU patients in a grade A tertiary hospital from 2017 to 2023 was retrospectively analyzed,and the data were statistically analyzed by SPSS 23.0 software.Results A total of 5166 pathogenic bacteria were detected,including 1612 multi-drug resistant organisms(MDROs).The most detected pathogens were Klebsiella pneumoniae,Acinetobacter baumannii,Escherichia coli,Pseudomonas aeruginosa,Enterococcus faecium,Staphylococcus aureus,Candida albicans and Candida tropicalis.The infection specimens were mainly from sputum,alveolar lavage fluid and urine,accounting for 66.37％.MDROs predominantly included multi-drug-resistant Acinetobacter baumannii(MDR-AB,518 strains),carbapenem-resistant Klebsiella pneumoniae(carbapenem-resistant KPN,526 strains),extended-spectrum P-lactamases-producing Escherichia coli(ESBLs-ECO,95 strains),and methicillin-resistant Staphylococcus aureus(MRSA,60 strains).The resistance rate of Acinetobacter baumannii to minocycline alone was 8.53％,and the drug resistance rate of other antibacterial drugs,including carbapenems,was high,even exceeding 80％.The resistance rates to most antibiotics of Klebsiella pneumoniae and Escherichia coli were higher than 50％.The drug resistance rate of Pseudomonas aeruginosa to ticacillin-clavulanate was 56.17％,and the drug resistance rate to other antibiotics was generally low.Conclusion The drug resistance of common pathogens in ICU patients had become relatively serious,among which the detection rates of carbapenem-resistant Klebsiella pneumoniae,Acinetobacter baumannii and Pseudomonas aeruginosa had increased significantly,which should be the focus of infection prevention and control.
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