Analysis of the pathogen distribution and drug susceptibility of fungal bloodstream infection in a hospital from 2017 to 2023
Objective To investigate the distribution and drug resistance of fungal bloodstream infections in the First Affiliated Hospital of Chengdu Medical College from 2017 to 2023 in order to provide a theoretical basis for antifungal drug use in clinical departments.Methods Fungal strains and clinical data detected in the blood cultures of patients in the First Affiliated Hospital of Chengdu Medical College from 2017 to 2023 were collected.Matrix-assisted laser desorption ionization time-of-flight mass spectrometry(VITEK-MS)and ATB FUNGUS 3 kits were used for strain identification and drug susceptibility tests,and the drug sensitive test results were statistically analyzed with WHONET 5.6 software.Results A total of 56 fungal strains were isolated from the blood culture specimens in the First Affiliated Hospital of Chengdu Medical College between 2017 and 2023.The top three strains were Candida albicans(18 strains,32.14％),Candida parapsilosis(12 strains,21.43％),and Candida glabrata(9 strains,16.07％).Infected patients's ages were concentrated between 51 and 80 years old,with the main departments being intensive care medicine(28.57％),neurosurgery(14.29％),neurology(12.50％),and gastroenterology(10.71％).The resistance rates of Candida albicans to amphotericin B,fluconazole and voriconazole were 0,5.56％and 5.56％,respectively.The resistance rate of Candida glabrata to itraconazole was higher than that of amphotericin B,and Candida parapsilosis had the highest resistance rate to fluconazole and voriconazole,both of which were 8.33％.Conclusion Candida albicans,Candida parapsilosis and Candida glabrata are the most common pathogenic bacteria for fungal bloodstream infections in our hospital.Middle-aged and elderly people with underlying medical conditions are high-risk groups.The clinical microbiology laboratory should pay enough attention to blood culture and drug-resistant strains to provide a basis for the rational use of antifungal drugs in clincial practice.Thus,drug-resistant fungi can be effectively controlled.
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