Basic and applied research on glycosylation and infection of pathogen proteins
Glycosylation is a crucial post-translational modification of proteins,playing a pivotal role in the infection caused by various pathogens.In viruses,glycosylation is involved in the recognition and entry processes between viruses and hosts,influencing viral replication and infectivity.Similarly,bacteria rely on glycosylation for the formation of flagellin and fimbrial proteins,which are essential for bacterial adhesion,colonization,infection,and immune evasion.This review provided a comprehensive summary of relevant studies elucidating the role and mechanism of pathogen protein glycosylation in infection.It offered valuable insights for further basic research on pathogen protein glycosylation and infection while laying a solid foundation for the development of carbohydrate-based drugs to combat infectious diseases.
Protein glycosylationInfectionMechanismCarbohydrate-based drugsTherapy
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