The continuous emergence and widespread prevalence of multidrug-resistant Gram-negative bacteria severely limit the selection of antimicrobial agents for anti-infective therapy,with the production of β-lactamases being the primary mechanism of resistance.Consequently,the development of inhibitors targeting β-lactamases has become a research hotspot.In recent years,several novel β-lactamase inhibitors have emerged or been introduced into clinical practice.The development of these inhibitors not only provides new hope for treating infections caused by multidrug-resistant Gram-negative bacteria but also offers important insights for the reuse and development of antimicrobial agents.This article delved into the chemical structures,antimicrobial mechanisms,and clinical applications of these inhibitors,aiming to provide more reliable guidance for clinical drug use.
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