Silver-catalyzed reduction of nitro to amines in water
Aromatic amines,an important basic chemical,are widely used in materials,medicinal chemistry and other fields.It is of great scientific significance to develop new and efficient catalytic synthesis strategies for the preparation of primary aromatic amines.In this study,the highly selective reduction of nitro was realized in the aqueous phase and under mild conditions by using commercial easily available aromatic nitro compound as raw material,cheap AgOTf as catalyst precursor,and phenylsilane as a reducing agent.The catalytic system with good compatibility,simple post-processing operation,and the avoidance of using the hydrogen and autoclave equipment,provided a new idea for the preparation of primary aromatic amines.The study on reaction mechanism showed that the silver hydrogen generated in situ was an active species,and the nitroaromatic compounds were converted into the corresponding nitrosoarenes,with azobenzene and hydrazobenzene as the intermediates.
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