Metal-based interventions in the immune"molecular machinery"
The recognition and regulation of the"molecular machinery"in the immune system are crucial for its proper functions.Metal elements,serving as essential nutrients in the body,possess unique chemical properties that can impact on the immune"molecular machinery"through various mechanisms.This review provides a comprehensive summary of the direct interventions and indirect influences of metals on the immune"molecular machinery"inside or outside cells.It elucidates the significant role that metal elements play in various immune"molecular machinery"and identifies the limitations and historical factors that contribute to the current research.Finally,through analyzing the chemical characteristics of metal interventions,this review suggests the integration of recent emerging research approaches to explore the global,specific,and variable aspects of metal interventions in order to provide fresh insights into metal-centered targeted interventions of the immune"molecular machinery".