Nucleic acid-based computation and its applications
Nucleic acid-based computation has garnered significant attention as an innovative computing paradigm,distinguished by the vast data storage capacity,superior parallel processing capabilities,compact design,and energy efficiency of nucleic acids.The molecular computing system mirrors the structure of electronic computation systems,encompassing three essential components:signal input,signal processing,and signal output.It has been successfully employed to perform arithmetic and logical operations,data processing,encryption,and the development of analog neural networks.Furthermore,its integration with other nanomaterials has paved the way for the creation of molecular machines,which hold promise for extensive applications across mathematics,medicine,and computer science.This comprehensive review delves into the principles,functionalities,and biomedical applications of nucleic acid computation.It underscores the advancements in molecular machine construction and concludes with an exploration of the challenges that lie ahead.