Recent progress in the design and antitumor application of iridium(Ⅲ)photosensitizers
Photodynamic therapy(PDT),which uses light-activated photosensitizers(PSs)to produce toxic substances for the treatment of tumors,is now an emerging solution for cancer treatment due to its specific spatiotemporal selectivity,non-invasiveness,and lack of susceptibility to drug resistance.In recent years,iridium(Ⅲ)complexes have attracted much attention as photosensitizers due to their excellent photophysical,photochemical,and photobiological properties.This article reviews the research progress of iridium(Ⅲ)complexes in the photodynamic therapy of tumors,focusing on iridium(Ⅲ)photosensitizers applied in one/two-photon photodynamic therapy as well as designed based on nanocomposite systems,which will provide a reference for the development of novel metal antitumor drugs.In addition,the research on iridium(Ⅲ)complexes in photodynamic immunotherapy in recent years is summarized to provide a new strategy for developing precise and efficient treatment of tumors.Finally,the prospect of iridium(Ⅲ)photosensitizers in cancer treatment is discussed and prospected.
iridium(Ⅲ)photosensitizerantitumorphotodynamic therapyimmunogenic cell deathnanocomposite system
万方数据
