Photodynamic therapy(PDT),which uses light-activated photosensitizers(PSs)to produce toxic substances for the treatment of tumors,is now an emerging solution for cancer treatment due to its specific spatiotemporal selectivity,non-invasiveness,and lack of susceptibility to drug resistance.In recent years,iridium(Ⅲ)complexes have attracted much attention as photosensitizers due to their excellent photophysical,photochemical,and photobiological properties.This article reviews the research progress of iridium(Ⅲ)complexes in the photodynamic therapy of tumors,focusing on iridium(Ⅲ)photosensitizers applied in one/two-photon photodynamic therapy as well as designed based on nanocomposite systems,which will provide a reference for the development of novel metal antitumor drugs.In addition,the research on iridium(Ⅲ)complexes in photodynamic immunotherapy in recent years is summarized to provide a new strategy for developing precise and efficient treatment of tumors.Finally,the prospect of iridium(Ⅲ)photosensitizers in cancer treatment is discussed and prospected.
关键词
铱光敏剂/抗肿瘤/光动力治疗/免疫原性细胞死亡/纳米复合体系
Key words
iridium(Ⅲ)photosensitizer/antitumor/photodynamic therapy/immunogenic cell death/nanocomposite system
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