In situ assembly of enzyme@hydrogen-bonded organic frameworks composites
Immobilization of natural enzymes using nanoconfinement effect is an efficient means to access a new generation of multifunctional and highly stable biocomposites.Hydrogen-bonded organic frameworks(HOFs),a class of porous materials formed by orderly connection of organic molecules via hydrogen bonding,feature with the merits of mild crystallization conditions,high backbone biocompatibility,rich chemical composition,high porosity and excellent solvent processability.The development of biocompatible assembly technology to regulate the in-situ growth of HOF on the surface of enzymes is a cutting-edge nanobiotechnology,which can reasonably integrate the framework chemistry of HOF and the biological function of enzyme molecules,gaining increasing attention in the interdisciplinary fields of chemistry,biological and materials science.In this review,we focus on the basic principles for the in situ assembly of enzyme@HOF biocomposites,and summarize the research progress of enzyme@HOF biocomposites in the domains of biosensing,protein delivery,antimicrobial therapy,nanomotors,and water remediation.Finally,we discussed the challenges facing this area and the way forward.
万方数据
