Higee-intensified process reengineering in fine chemistry industry:principle and case studies
Fine chemicals have played an important role in fields such as advanced manufacturing,special materials,and human health.However,the materials involved in fine chemical reactions are mostly characterized by toxic,flammable and explosive.Moreover,the operation is usually in batch/semi-batch mode,which brings low level of automation and potential safety risks.For the established fine chemical processes,it has become a research hotspot to achieve the goals of simplifying the process,reducing the amount of working materials,converting into continuous operation mode,and improving inherent safety via process reengineering.Based on the researches of our group,a strategy of process reengineering for fine chemicals production via Higee technology was proposed.According to the principle that the Higee devices can intensify the transfer rate to match the reaction rate,the Higee-intensified integration technology featuring continuity and short process was developed.Case studies were carried out taking oxidation,fluorination,azotization,alkylation,chlorination and other processes as examples to clarify the effects of Higee-intensified process reengineering.
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