A novel and long-lasting crosslinked yak collagen implant for skin rejuvenation
As the largest organ of the human body,the skin serves as a protective barrier against the external environment.However,under the influence of various factors,the skin undergoes gradual aging and may even predispose individuals to skin cancer.The degradation of collagen stands as the primary culprit behind skin aging.However,currently collagen implants were susceptible to degradation.The durability of crosslinked collagen implants was enhanced;however,the utilization of crosslinking agents may entail the risk of cytotoxicity and tissue calcification,thereby constraining their clinical utilization.In this study,a novel and durable crosslinked yak collagen implant was developed for skin rejuvenation.Employing a low concentration of crosslinking agent efficiently facilitated the formation of collagen fibers with a thicker,and more uniform network structure.Post-crosslinking,the resultant yak collagen implant exhibited commendable mechanical strength and long-lasting.Furthermore,crosslinked yak collagen demonstrated remarkable thermal stability and durability.Furthermore,the crosslinked yak collagen implant effectively promoted cell proliferation and adhesion.Following subcutaneous implantation in mice,the crosslinked yak collagen implant effectively stimulated the regeneration of collagen and demonstrated commendable potential in resisting calcification.The crosslinked yak collagen implant effectively fosters collagen regeneration and holds considerable potential in the realm of skin rejuvenation treatment.
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