A novel and long-lasting crosslinked yak collagen implant for skin rejuvenation
王琪 1闫荟宇 1张靖廷 1李文华 1肖建喜 1Linyan Yao2
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作者信息
1. 兰州大学化学化工学院,兰州 730000;甘肃省医用胶原蛋白工程研究中心,兰州 730000
2. State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering,Lanzhou University,Lanzhou 730000,China;Gansu Engineering Research Center of Medical Collagen,Lanzhou 730000,China
As the largest organ of the human body,the skin serves as a protective barrier against the external environment.However,under the influence of various factors,the skin undergoes gradual aging and may even predispose individuals to skin cancer.The degradation of collagen stands as the primary culprit behind skin aging.However,currently collagen implants were susceptible to degradation.The durability of crosslinked collagen implants was enhanced;however,the utilization of crosslinking agents may entail the risk of cytotoxicity and tissue calcification,thereby constraining their clinical utilization.In this study,a novel and durable crosslinked yak collagen implant was developed for skin rejuvenation.Employing a low concentration of crosslinking agent efficiently facilitated the formation of collagen fibers with a thicker,and more uniform network structure.Post-crosslinking,the resultant yak collagen implant exhibited commendable mechanical strength and long-lasting.Furthermore,crosslinked yak collagen demonstrated remarkable thermal stability and durability.Furthermore,the crosslinked yak collagen implant effectively promoted cell proliferation and adhesion.Following subcutaneous implantation in mice,the crosslinked yak collagen implant effectively stimulated the regeneration of collagen and demonstrated commendable potential in resisting calcification.The crosslinked yak collagen implant effectively fosters collagen regeneration and holds considerable potential in the realm of skin rejuvenation treatment.
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