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双频微波热声成像方法及应用研究

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为解决传统微波热声成像技术对含有骨骼的复杂生物组织难以完整清晰重建的问题,本文提出新型双频微波热声成像技术.即利用两个不同中心频率短脉宽微波激励组织得到两组单频微波热声数据,两组数据利用区域像素均值与区域吸收系数补偿进行能量校准后,以骨骼在不同频率下微波能量吸收系数的比值进行加权相减,最后得到减小骨骼副作用的双频微波热声图像.本文首先对双频微波热声成像方法的原理进行了研究,然后介绍了搭建的双频微波热声成像系统,最后进行了兔膝关节与鸡跖骨成像实验,并对成像结果进行了定性观察与半定量量化分析.实验结果表明,与单频微波热声成像相比,双频微波热声成像中的组织估算尺寸和微波热声信号趋势与相应的组织实际尺寸和理论分析更加符合.双频微波热声成像技术能够减小骨骼的"负造影"作用带来的影响,从而使受此作用影响的半月板、交叉韧带和骨髓腔清晰完整重建.综上,此方法能够提高微波热声成像技术对含骨复杂生物组织的成像能力,从而推动相关应用研究的进展,并为需要缓解骨骼副作用的其他影像学方法提供参考.
Dual-frequency microwave-induced thermoacoustic imaging method and its application
To solve the problem regarding the difficulty of the traditional microwave-induced thermoacoustic imaging technology to reconstruct complex biological tissues containing bones completely and clearly,this study proposes a new dual-frequency microwave-induced thermoacoustic imaging technology.That is,two sets of single-frequency microwave-induced thermoacoustic data were obtained by exciting tissues with two different center frequencies'short pulse width microwave.After energy calibration of the above two sets of data using regional pixel mean and tissue absorption coefficient compensation,the ratio of the bone's microwave energy absorption coefficients at two different frequencies is used to weigh and subtract the above two sets of calibrated data.Thereafter,dual-frequency microwave-induced thermoacoustic images were finally obtained to reduce the side effects of bone.In this paper,the principle of the dual-frequency microwave-induced thermoacoustic imaging method is first described in detail.Next,the dual-frequency microwave-induced thermoacoustic imaging system is introduced.Finally,imaging experiments of rabbit knee joints and chicken metatarsal bones are conducted,and the imaging results are qualitatively observed and semiquantitatively analyzed.The experimental results show that compared with single-frequency microwave-induced thermoacoustic imaging,the estimated tissue dimensions and signal trends in dual-frequency microwave-induced thermoacoustic imaging are more consistent with the corresponding actual tissue dimensions and theoretical analysis.Dual-frequency microwave-induced thermoacoustic imaging technology can reduce the"negative contrast"effect of the bone so that the affected meniscus,cruciate ligament,and bone marrow cavity can be clearly and completely reconstructed.This method can improve the imaging ability of microwave-induced thermoacoustic imaging technology for complex biological tissues containing bones,thus promoting the progress of related applied research and providing a reference for other imaging methods to alleviate side effects on bones.

traditional microwave-induced thermoacoustic imaging technologydual-frequency microwave-induced thermo-acoustic imaging methodmicrowave energy absorption coefficientbone negative contrast

刘悦、迟子惠、王阳、方秋潮、杜爽、吴丹、蒋华北

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重庆邮电大学光电工程学院,重庆 400065

Department of Medical Engineering,University of South Florida,Tampa 33620,USA

传统微波热声成像技术 双频微波热声成像方法 微波能量吸收系数 骨骼负造影

国家自然科学基金项目重庆市博士后研究项目特别资助项目重庆市教育委员会科学技术研究项目

620010752021XM2026KJQN202000610

2024

10.1360/SST-2022-0252

中国科学(技术科学)
中国科学院

中国科学(技术科学)

CSTPCD北大核心
影响因子：0.752
ISSN：1674-7259
年,卷(期)：2024.54(2)
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