The increasing population aging directly correlates with the heightened prevalence of chronic ailments,including osteoporosis and cardiovascular diseases.This poses considerable challenges to clinical treatments focused on tissue repair materials.In this review,an overview of the developmental trajectory of biomaterials is provided,along with a discussion on the merits and demerits associated with their different developmental stages.Furthermore,intricacies involved in maintaining tissue function and microenvironment homeostasis during the aged and damaged tissue repair are analyzed.Lastly,building upon these insights,the utilization of emerging technologies,such as artificial intelligence,material biology,and imaging omics,for developing novel"adaptive"intelligent biomaterials capable of perceiving physiological and pathological microenvironments is explored.These materials would promptly respond and actively regulate biological effects during the entire tissue repair process at lesion sites.
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