Comparison of the clinical outcomes between fresh embryo transfer and frozen-thawed embryo transfer in the gonadotropin-releasing hormone antagonist protocol
Objective To compare the clinical outcomes of fresh embryo transfer and frozen-thawed embryo transfer(FET)in the gonadotropin-releasing hormone antagonist(GnRH-A)protocol.Method The clinical data of 2575 women undergoing GnRH antagonist protocol cycle,including 1328 cases of fresh embryo transfer and 1247 cases of FET were retrospectively analyzed.Results The AMH level and AFC in the FET group were significantly higher than those in the fresh embryo transfer group(P＜0.05),and there was no significant difference in other baseline characteristics between the two group(P＞0.05).The FSH level on hCG day in the FET group was significantly lower than that in the fresh embryo transfer group,and E2,P level on hCG day in the FET group were significantly higher than those in the fresh embryo transfer group(P＜0.05).The total number of oocytes retrieved,matured oocyte,high-quality embryos in the FET group were significantly higher than those in the fresh embryo transfer group(P＜0.05).The mean number of embryos transfer in the FET group was significantly lower than that in the fresh embryo transfer group,the clinical pregnancy rate,implantation rate and live birth rate in the FET group were significantly higher than those in the fresh embryo transfer group,the ectopic pregnancy rate and the multiple pregnancy rate in the FET group were significantly lower than those in the fresh embryo transfer group(P＜0.05).There was no significant difference in the incidence of moderate-severe OHSS,miscarriage rate,incidence of GDM and gestational hypertension between the two groups(P＞0.05).The singleton birth weight in the FET group was significantly higher than that in the fresh embryo transfer group,with statistical difference(P＜0.05).Conclusions In the GnRH antagonist protocol cycle,FET can obtain good clinical outcome and can be used as an effective supplemental regimen.
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