Objective To investigate the efficacy of Oxford Shoulder Score(OSS)for preventing postoperative ipsilateral shoulder pain(ISP)in patients undergoing thoracoscopic surgery.Methods A total of 500 patients who underwent selective thoracoscopic surgery in the lateral position with general anesthesia were enrolled.Complete OSS data were questioned using in-depth interviews in the afternoon before the operation and the first postoperative day,and telephone was follow-up at 4-6 weeks after the operation.Special protections and statistical analysis were designed for the patients with preoperative OSS ≥19.Results A total of 465 patients were included in the study,16 cases presented ISP with a longer operative duration and higher postoperative OSS compared to those without ISP,and shown limitation of range of motion of ipsilateral shoulder in the first postoperative day(P<0.05 or 0.01).However,9 cases with preoperative OSS ≥19 didn't develop ISP.Conclusions The protective procedures of the lateral posture can minimize postoperative ISP for the patients with a high preoperative OSS.