Lateralization and sex differences of hippocampal subregions volume in adolescents
Objective To make a detailed subdivision of the hippocampus in adolescents and to analyze the lateralization and sex differences in the volume of each subregion,so as to provide anatomical basis for the study of hippocampal function and related psychiatric diseases.Methods A total of 101 healthy adolescent subjects were collected for 3.0T brain magnetic resonance imaging.After whole-brain segmentation and subregion segmentation of bilateral hippocampus by using FreeSurfer software,intracranial volume and each hippocampal subregion volume were obtained.The volumes of hippocampal subregions were standardized by intracranial volume using Cendes methods.Finally,the lateralization and sex differences of hippocampal subregion volumes after standardization were statistically analyzed.Results Freesurfer software showed clear and good effect in automatic segmentation of hippocampal subregions.In terms of literalization,the HBT(head/body/tail)protocol showed that,except for the hippocampus tail,there were literalization in the volume of the hippocampus head,body and the whole hippocampus,right(R)＞left(L).In FS60,there was no literalization in hippocampal tail,hippocampal fissure and subiculum;other subregions had literalization,the volume of CA1,CA3,CA4,GC-ML-DG,molecular layer,HATA,fimbria was R＞L,while parasubiculum and presubiculum was L＞R.In terms of sex difference,after data standardized by the Cendes method,there was sex difference in the volume of each part on the both sides of the HBT,and female(F)＞male(M).For FS60,there was sex difference in parasubiculum,presubiculum,subiculum,CA4,GC-ML-DG,molecular layer,HATA,and hippocampal tail,F＞M.Conclusions The volumes of different hippocampal subregions in adolescents have different lateralization and sex differences properties,reflecting the heterogeneous structural characteristics of the hippocampus in this period.This study provides basis for the study of the formation of functional lateralization of the brain and related clinical psychiatric disorders.
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