Analysis of COL4A1 expression in cholangiocarcinoma
Objective To explore the molecular mechanisms underlying the development of cholangiocarcinoma.Methods The dataset GSE89749 was downloaded from the GEO database,and differential gene analysis,GO/KEGG enrichment analysis,and protein-protein interaction(PPI)analysis were sequentially performed to identify key genes.The expressions of COL4A1 in 16 types of cancers,including adrenocortical carcinoma,bladder urothelial carcinoma,and invasive breast carcinoma,were analyzed in the TCGA database.Results Differential gene and GO/KEGG enrichment analysis showed that differential genes were significantly enriched in the extracellular matrix containing collagen.PPI analysis identified the gene COL4A1 as a key gene.COL4A1 was found to be highly expressed in cholangiocarcinoma,colorectal cancer,and esophageal cancer among 8 types of cancers.Conclusions COL4A1 is significantly over-expressed in cholangiocarcinoma tissues,providing new perspective and experimental basis for exploring the molecular mechanisms of cholangiocarcinoma development.
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