KDELR2在胶质瘤中的表达及临床意义:基于组织芯片技术分析
Expression of KDELR2 in glioma tissues and its clinical significance:an analysis based on tissue microarray technology
张娇 1黄纯海 1毛辉1
作者信息
- 1. 416000 湖南吉首,湘西自治州人民医院(吉首大学第一附属医院)神经外科
- 折叠
摘要
目的 探讨KDELR2在脑胶质瘤中的表达及其与胶质瘤病人临床特征、病理特征和预后的关系.方法 选择组织芯片HBraG180Su01作为实验标本,收集并整理完整的临床资料.免疫组化染色检查胶质瘤组织KDELR2的表达,分析KDELR2的表达水平与胶质瘤病人临床特征、病理特征以及预后的关系.结果 最终纳入165例胶质瘤.免疫组化染色显示,KDELR2主要表达于胶质瘤细胞的细胞质.胶质瘤KDELR2表达阳性率高达98.18%;KDELR2表达水平与胶质瘤WHO分级、复发状态、PDL1表达及病人年龄、生存状态呈显著相关(P<0.05),与胶质瘤Ki-67、EGFR表达及病人性别无明显关系(P>0.05).Cox比例回归风险模型分析显示,KDELR2高表达是胶质瘤病人生存预后不良的独立危险因素(P<0.05);生存曲线分析显示,KDELR2高表达组总体生存期和无进展生存期较KDELR2低表达组明显缩短(P<0.05).结论 胶质瘤KDELR2呈高表达,与胶质瘤WHO分级、复发显著相关,并与胶质瘤病人的生存预后显著相关.这提示KDELR2可作为胶质瘤靶向治疗的一个潜在靶点.
Abstract
Objective To investigate the expression of KDELR2 in glioma tissues and its relationship with clinical and pathological features,and prognosis of glioma patients.Methods The HBraG180Su01 tissue microarray was selected as the experimental specimen,and their clinical data were collected.Immunohistochemical staining was used to detect the expression of KDELR2 in glioma tissues,and the relationships between KDELR2 expression level and clinical and pathological features,and prognosis of glimoa patients were analyzed.Results A total of 165 glioma cases were finally included.Immunohistochemical staining showed that KDELR2 was mainly located in the cytoplasm of glioma cells.The positive rate of KDELR2 expression in glioma tissues was as high as 98.18%.KDELR2 expression level was significantly correlated with WHO grade,recurrence status,and PDL1 expression,patients'age,and survival status(P<0.05),but not significantly correlated with patients'gender,and expression levels of Ki-67 and EGFR(P>0.05).Cox proportional hazards regression risk model analysis showed that high expression of KDELR2 was an independent risk factor for poor survival of glioma patients(P<0.05).Kaplan-Meier survival curve analysis showed that the overall survival and progression-free survival of patients with high expression of KDELR2 were significantly shorter than those with low expression of KDELR2(P<0.05).Conclusions KDELR2 is highly expressed in gliomas,is significantly correlated with WHO grade,tumor recurrence,and patients'prognosis.Our results suggest that KDELR2 may be a potential target for therapy of gliomas.
关键词
脑胶质瘤/KDELR2/组织芯片/预后/基因表达Key words
Glioma/KDELR2/Tissue microarray technology/Prognosis/Gene expression引用本文复制引用
基金项目
湖南省卫健委课题(202104091193)
吉首大学第一附属医院指导性项目(Jdlc2002)
出版年
2024
NETL
NSTL
万方数据