Objective To investigate the role of using artificial dura mater patch in replacing autologous dura mater suture in reducing the incidence of complications after placement of subdural electrodes.Methods The clinical data of 308 patients who underwent subdural electrode implantation from January 2008 to December 2021 were retrospectively analyzed.Of the 163 patients who underwent the operation from January 2008 to December 2013,the autologous dura mater was sutured in situ(autologous dura mater group).Of the 145 patients who underwent the operation from January 2014 to December 2021,artificial dura mater patch was used(artificial dura mater group).The surgical evaluation and operation were performed by the same treatment team for both groups,and the surgical procedures were kept consistent except for the way of handling the dura mater.Results The rates of postoperative intracranial hemorrhage(7.97%)and cerebrospinal fluid leakage(13.50%)in the autologous dura mater group were significantly higher than those(2.76%and 4.83%,respectively)in the artificial dura mater group(P<0.045).There was no statistically significant difference in the incidence of postoperative intracranial infection(3.07%vs.2.07%)between the two groups(P>0.045).Conclusion The use of artificial dura mater patch in place of autologous dura mater suture in subdural electrode implantation can reduce the incidence of postoperative intracranial hemorrhage and cerebrospinal fluid leakage.