Glioblastoma multiforme(GBM)is the most common and highly malignant primary brain tumor in the adult central nervous system.Even with comprehensive treatments such as surgical tumor resection combined with postoperative concurrent chemoradiotherapy,the prognosis of GBM patients remains very poor.Metabolic abnormality is one of the significant hallmarks of tumor cells.The remodeling of amino acid metabolism has gradually become a research hotspot in oncology.Aberrant amino acid metabolism can provide an energy basis for tumor cells,offer raw materials for oncogene expression,and supply ligands for oncogene activation,thereby playing a crucial role in tumorigenesis and development.A better understanding of amino acid metabolic remodeling can offer new targets for the immunotherapy of GBM.This article reviews the metabolism of tryptophan,arginine,and glutamate in GBM and their influences on the immune microenvironment,with the hope of pointing out the direction for the next step of research.
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