Glioma is the most common malignant tumor in the central nervous system,and even with combined treatment regimens(surgery followed by postoperative radiation/chemotherapy),the outcomes are not satisfactory,with poor prognosis.Therefore,understanding the pathophysiological mechanisms of glioma is of great importance.N6-methyladenosine(m6A)modification is the most common form of RNA post-transcriptional modification,playing an important role in virtually all biological processes.m6A is a highly abundant important transcriptomic marker in the central nervous system and plays a crucial role in neural development.Recent studies have shown that m6A modification is associated with the occurrence and development of glioma,especially glioblastoma,but research on the role of m6A modification in glioma is still in the starting stage.This review summarizes the advances in the role of m6A modification in the occurrence,development,treatment,and prognosis assessment of glioma.
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