Glioblastoma is the most common malignant tumor in the central nervous system,characterized by high recurrence rate,short survival time,and high mortality rate.β-Elemene is a broad-spectrum anti-tumor drug that exerts anti-tumor effects through multiple mechanisms,including inhibition of cell proliferation,blockage of cell cycle,and induction of cell apoptosis.This article reviews the existing basic research and related achievements to summarize the mechanisms of β-elemene in inhibiting glioblastoma,with the aim of providing reference for its clinical application and further research.