Objective To explore the effects of anesthesia method and microelectrode recording(MER)on the outcome of deep brain stimulation(DBS)for patients with Parkinson's disease(PD).Methods The clinical data of 112 PD patients who underwent bilateral subthalamic nucleus(STN)-DBS from January 2016 to December 2020 were retrospectively analyzed.According to the anesthesia method and the use of MER,they were divided into 4 groups:local anesthesia(LA)+MER group(n=22),LA+non-MER group(n=25),general anesthesia(GA)+MER group(n=34),and GA+non-MER group(n=31).The postoperative complications were recorded;the coordinates of the target and the actual electrode tip were calculated by postoperative CT images,and the Euclidean distance(ED)was used to assess the accuracy of electrode implantation;the stimulator was activated 1 month after the surgery,and the UPDRS-Ⅲscore was used to assess the therapeutic effect.Results The improvement rate of UPDRS-Ⅲscore 1 month after the surgery:the LA+MER group[(50.04±7.20)%],the GA+MER group[(51.80±8.04)%],and the GA+non-MER group[(52.23±7.92)%]were significantly higher than the LA+non-MER group[(40.37±9.76)%;P<0.05].Intracranial pneumatosis:the LA+MER group[(8.17±5.38)ml]and the LA+non-MER group[(10.27±4.22)ml]were significantly higher than the GA+MER group[(4.68±1.25)ml;P<0.05]and the GA+non-MER group[(4.75±1.08)ml;P<0.05].Compared with the other three groups,the Y-axis deviations of the first and second targets in the LA+non-MER group were significantly increased(P<0.05).Conclusions The choice of anesthesia method and MER has a certain influence on the outcomes of STN-DBS for PD patients.The use of MER can correct the target errors caused by cerebrospinal fluid loss and body position under GA and improve the accuracy of electrode implantation.
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