Objective To explore the risk factors for intra-abdominal hypertension(IAH)in critically ill neurosurgical patients after enteral nutrition.Methods The clinical data of 123 critically ill neurosurgical patients who received enteral nutrition treatment in the neurosurgical intensive care unit from June to December 2022 were retrospectively analyzed.After enteral nutrition treatment,a pressure sensor is connected to the end of the urinary catheter to monitor the abdominal pressure.A continuous increase of>12 mmHg is termed as IAH.Results Among the 123 critically ill neurosurgical patients receiving enteral nutrition,38 patients(30.89%)had IAH.Multivariate logistic regression analysis revealed that sedative drugs and feeding intolerance were independent risk factors for IAH after enteral nutrition in critically ill neurosurgical patients(P<0.05),while naso-intestinal tube feeding and normal serum albumin were protective factors(P<0.05).Conclusions The incidence of IAH during the implementation of enteral nutrition in critically ill neurosurgical patients is relatively high.Sedative drugs,naso-intestinal tube feeding,serum albumin,and feeding intolerance are the influencing factors for IAH after enteral nutrition in critically ill neurosurgical patients.In clinical practice,early warning plans should be formulated with reference to these factors to improve the prognosis of patients.