Acute traumatic brain injury(TBI)is the primary cause of traumatic death and neurological dysfunction.After the initial trauma,secondary injuries such as hypotension,hypoxia,and intracranial hypertension will further exacerbate brain injury.The focus of pre-hospital emergency treatment and care for TBI lies in preventing secondary brain injury through stabilizing the condition at the scene and promptly transporting to a suitable hospital.Timely and effective pre-hospital emergency treatment measures and early nursing interventions,such as correcting hypotension and hypoxia,and preventing cerebral edema,can significantly reduce the risk of secondary injury.Pre-hospital emergency treatment,as the primary link in the treatment of TBI,is of self-evident importance;while the rapid response in the hospital,multidisciplinary collaboration,emergency rescue and safe transportation are specific manifestations of efficient treatment.Achieving seamless connection between pre-hospital and in-hospital treatment and the integrated rescue process of the trauma center can significantly shorten the treatment time and thereby increase the success rate of rescue.This paper conducts a comprehensive review of the integrated rescue and transport process management model for pre-hospital and in-hospital TBI,with the aim of providing a useful reference for clinical practice.