Objective To investigate the clinical efficacy of Ruimi robot-assisted percutaneous microballoon compression (PBC) for patients with primary trigeminal neuralgia (PTN). Methods A retrospective analysis was conducted on the clinical data of 30 patients with PTN who underwent Ruimi robot-assisted PBC from January 2021 to June 2022. Results All 30 patients successfully registered and completed the operation. Among them,16 patients had a successful single puncture,and 14 patients required adjustments. The intraoperative lateral DSA images revealed that the microballoon in the Meckel's cavity presented a typical "pear-shaped" form. Immediately after the operation,the pain was significantly alleviated in all patients,and the VAS score was significantly lower than that before the operation (P<0.05);during the 6-month follow-up,there was no recurrence of pain. Immediately after the operation,4 cases (13.3%) presented with masticatory muscle weakness,and 2 cases (6.7%) had ipsilateral sensory abnormalities. Immediately after the operation,all patients had facial numbness,among which 15 cases were mild,and 15 cases were moderate to severe;at 6 months after the operation,the degree of facial numbness was partially relieved,among which 22 cases were mild,and 8 cases were moderate to severe. Conclusion Ruimi robot-assisted PBC in the treatment of PTN has the advantages of precise positioning and safety,and is a feasible and effective surgical method.