Objective To explore the clinical efficacy of middle meningeal artery embolization (MMAE) in the treatment of chronic subdural hematomas (CSDH).Methods The clinical data of 12 patients with CSDH treated with MMAE from January 2020 to January 2022 were retrospectively analyzed.Results Three cases had bilateral hematomas,and nine cases had unilateral ones.A total of 15 MMAEs were performed in 12 patients,among which 9 were treated with embolization alone and 6 were treated with adjunctive embolization after burr hole drainage.The embolic agents included microsphere particles in 9 cases,Onyx glue in 5 cases,and coils combined with particles in 1 case.After the operation,one case had permanent monocular blindness,and two cases had pain in the mandibular nerve region.During the 3~6 months of follow-up after the operation,the hematoma volume of all patients was significantly reduced or absorbed,and no recurrence of hematoma was observed.Conclusion MMAE is an effective method for preventing the progression and recurrence of CSDH.However,in the early stage of implementation,careful identification of meningeal vascular variations and anastomoses is necessary to prevent serious complications.