Epilepsy is a clinical syndrome resulting from highly synchronized abnormal discharges of neurons caused by multiple factors.Most epilepsy can be effectively controlled through drug treatment;however,a portion of epilepsy patients show a poor response to antiepileptic drug therapy and have difficult-to-control seizures,which are referred to as refractory epilepsy.Currently,epilepsy focus resection is the main treatment method for refractory epilepsy,and the key to a successful resection lies in the accurate identification of the epileptogenic focus.Nevertheless,accurately locating the epileptogenic focus has consistently been a challenge in neurosurgery.Previously,the epileptogenic focus was mainly located through spike waves in the electroencephalogram (EEG).In 2006,high-frequency oscillations was found in the intracranial EEG of patients with focal epilepsy.In recent years,research has indicated that high-frequency oscillations can delineate the boundaries of the epileptogenic focus more specifically than spike waves and can serve as a new physiological marker of the epileptogenic focus.This article primarily reviews the research progress of high-frequency oscillations based on magnetoencephalography in refractory epilepsy.
关键词
难治性癫痫/癫痫灶切除术/高频振荡/脑磁图
Key words
Drug resistant epilepsy/High frequency oscillations/Magnetoencephalogram
维普
万方数据