Objective:This study aims to investigate the impact of maternal risk exposure during pregnancy on the brain structure and function of children with anxiety disorders and its subtypes.Methods:In this cross-sectional analysis,the da-ta included 5686 children(average age:9.95 years old,2743 children with anxiety disorders)obtained from ABCD(Adoles-cent Brain Cognitive Development)database.Linear mixed-effects model was employed to compare the differences in preg-nant risk factors,brain structure,and resting-state functional connectivity among the anxiety group,anxiety subtype group,and the healthy control group.We also examined the relationship between maternal prenatal risk factors and children's brain structure along with resting-state functional connectivity.Results:①Compared to the healthy group,children in the anxiety group exhibited more maternal risk exposure during pregnancy(e.g.,the experience of medical care),thicker corti-cal thickness in the superior temporal gyrus,smaller surface area in the insula,and enhanced functional connectivity be-tween the cingulate-parietal network and the caudate nucleus.②Mothers'peripartum medical care was associated with children's increased thickness of the left superior temporal gyrus.③Prenatal risk exposures(e.g.,severe anemia,medical care)were identified as common risk factors for children's anxiety disorder and its subtypes,and abnormalities also ob-served in brain structure and connectivity in children.Conclusion:Maternal risk exposure during pregnancy is a critical risk factor for childhood anxiety disorders,and its long-term effects may be attributed to abnormalities in brain structure and function.
关键词
儿童焦虑症/脑结构/静息态功能连接/母亲孕期风险暴露
Key words
Children anxiety disorder/Brain structure/Resting state brain functional connectivity/Maternal pregnant risk exposure
维普
万方数据