Objective:To investigate abnormal thalamocortical functional connectivity in drug-naïve adolescents with early-onset schizophrenia.Methods:Sixty-one patients and fifty-five matched healthy controls underwent resting-state fMRI scanning and accepted the PANSS assessment.And seed-based functional connectivity analysis was adopted using 16 thalamic subregion atlases as ROIs.Results:There were thalamic hyperconnectivity with a broad area of sensorimotor regions and thalamic hypoconnectivity with striatum,amygdala anteriorcingulate cortex,and orbitofrontal cortex in pa-tients.Conclusion:The present study suggest that marked thalamic hyperconnectivity with sensorimotor areas is critical for the expression of schizophrenia phenotype irrespective of the onset age,and thalamic dysconnectivity also affected the extended limbic structures,which is possibly related to the untreated socio-emotional deficits.
维普
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