The incidence of suicide has increased in recent years,and the consequences are quite severe.However,the mechanism of suicide remains unclear.Along with the advancement of neuroscience,the role of neurobiological factors in suicide has begun to get increasing attention.As an important part of the central nervous system,microglia have a great im-pact on neurotransmitter metabolism,immune regulation and neuroinflammation.Overactivated microglia are thought to play an important role in the development of suicide.This article reviewed the relationship between suicide and microglia,as well as the role of microglia in the mechanisms of neuroinflammation,neuroimmune and stress on suicidal behavior.It is expected to provide research directions for the study of the mechanism of suicide,and provide a theoretical basis for the for-mulation of suicide prevention strategies.
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