Correlations between Metabolic Disorders and Cognitive Impairment in Schizophrenia
Objective:To explore the changes of metabolism and cognitive function in patients with schizophrenia after weight gain and their associations.Methods:Patients with schizophrenia and healthy controls were recruited.Patients were divided into two groups based on whether they gained weight by ≥7％during antipsychotic treatment.Participants complet-ed MATRICS Consensus Cognitive Suite Battery(MCCB)and had their height,weight,waist and hip circumferences mea-sured,as well as fasting serum glucose,triglycerides,total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and insulin tested.Results:Compared with the non-weight gain group,the weight gain group had more abnormal metabolic parameters and worse MCCB performance.In patients with schizophrenia,body weight and body mass index(BMI)were negatively correlated with neurocognitive scores,and abnormal blood lipid profile was associated with social cognitive impairment.Conclusion:Patients with schizophrenia who gain weight have more metabolic abnormalities and worse cognitive impairment.Metabolic disorders are associated with cognitive impair-ment in schizophrenia.
万方数据
维普
