Effects of Group Exercise Intervention on Gut Microbiota in Children with Autism Spectrum Disorders
Objective:To investigate the differences in gut microbiota between children with autism spectrum disorder(ASD)and healthy immediate family members,and the effects of group exercise intervention on gut microbiota and behavior in autistic children.Methods:4 children with ASD participated in exercise intervention for 15 times and 1 hour each time.The control was 8 healthy immediate family members.16S rRNA high-throughput sequencing was used to analyze the intes-tinal microbiota in children with ASD before and after exercise intervention.Changes in behavioral symptoms of children with ASD were further evaluated by Autism Treatment Evaluation Checklist.Results:The abundance of Erysipelotrichace-ae in children with ASD was significantly higher than that in typical developmental siblings before intervention,and there was no significant decrease after exercise intervention.In addition,the abundance ratio of Firmicutes to Bacteroidetes in children with ASD obviously declined after exercise intervention.Interestingly,the sociability of children with ASD im-proved after exercise intervention,and there was a significant positive correlation with bacterial Bacteroidetes.Conclusion:The abundance of harmful bacteria in children with ASD is significantly higher than typical developing siblings.Exercise in-tervention is beneficial to the improvement of social function of children with ASD by increasing the abundance of Bacte-roidetes.
国家科技期刊平台
NSTL
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