Clinical trial of the therapeutic effect of ritodrine hydrochloride on pregnant women with threatened abortion in the second trimester of pregnancy
Objective To observe the effect of ritodrine hydrochloride on uterine blood flow,progesterone,serum D-dimer(D-D),left ventricular ejection fraction(EF)and stroke volume(SV)in pregnant women with threatened abortion in the second trimester of pregnancy.Methods Pregnant women with threatened abortion in the second trimester were included in the study.The control group was treated with intravenous drip of 25％magnesium sulfate 15 g,qd,for 3 d.The treatment group was treated with intravenous drip of ritodrine hydrochloride 100 mg and the intravenous drip lasted for 12-18 h after uterine contraction stopped.Then,patients in the group were treated with ritodrine tablets(10 mg/2 h in the former 24 h and then 10 mg/4-6 h)no more than 120 mg every day,for 3 d.Uterine hemodynamics[resistance index(RI),pulsatility index(PI)and systolic/diastolic ratio(S/D)],progesterone[progesterone(P),human chorionic gonadotropin(HCG)and estradiol(E2)],serum D-D,EF,SV,disappearance time of symptoms,success rate of fetal protection,adverse neonatal outcomes,and adverse drug reactions were compared between two groups.Results After treatment,RI in the treatment group and the control group were 0.74±0.13 and 0.81±0.17;PI were 2.08±0.39 and 2.63±0.42;S/D were 3.14±0.57 and 3.65±0.62;D-D levels were(0.60±0.12)and(0.58±0.13)mg·L-1;P levels were(44.83±7.62)and(41.35±7.96)μg·L-1;HCG levels were(20 958.63±2 143.72)and(20 043.82±2 125.64)mU·mL-1;E2 levels were(538.72±83.16)and(503.69±87.42)ng·L1;EF were(61.34±8.05)％and(72.52±8.37)％;SV were(75.06±7.92)and(80.29±8.34)mL;the disappearance time of bleeding were(2.65±0.43)and(2.87±0.39)d;the disappearance time of abdominal pain were(2.57±0.38)and(2.80±0.42)d;the disappearance time of soreness of waist were(2.36±0.35)and(2.74±0.38)d;the success rates of fetal protection were 98.04％and 77.55％;the premature delivery rates were 12.00％and 18.42％;the incidence rates of adverse neonatal outcomes were 6.00％and 10.53％;there were statistically significant differences between the treatment group and the control group except for D-D,preterm delivery rate,and the incidence of neonatal adverse outcomes(all P＜0.05).The total incidence of adverse drug reactions in the treatment group and the control group were 7.84％and 6.12％,respectively,and the difference were not statistically significant(P＞0.05).Conclusion Ritodrine hydrochloride can effectively improve uterine hemodynamics,increase progesterone levels,and achieve good fetal protection effect in pregnant women with threatened abortion in the second trimester of pregnancy.
ritodrine hydrochloridethreatened abortionuterine blood flowprogesteronecardiac function
国家科技期刊平台
NSTL
万方数据
维普
