Effects of astragalus polysaccharide on proliferation and invasion of triple negative breast cancer cells
Through biological analysis of breast cancer data in gene expression omnibus(GEO),The Cancer Genome Atlas(TCGA)and other databases,this study screened the differentially expressed genes in triple-negative breast cancer compared with other breast cancer subtypes,so as to mine drug targets according to its characteristics and provide some reference for the identification and prognosis of triple-negative breast cancer.Based on the analysis of bio-informatics,it showed that triple negative breast cancer has characteristic manifestations in the process of cell cycle and estrogen signaling pathway.The screened 10 hub genes can better predict and diagnose triple negative breast cancer.The drug targets exploring rusults suggest that pyrazolanthrone,alvocidib and so on are potential drugs which have research and development value.
triple negative breast cancerbioinformaticsdifferential genedrug target
国家科技期刊平台
NSTL
万方数据
维普
