缺血性脑卒中的侧支循环建立及治疗的研究现状
Research status on establishment of collateral circulation and therapy in ischemic stroke
孙锦 1郭莉琛 1王萌 1苏琳琳 1袁庆 1胡利民1
作者信息
- 1. 天津中医药大学组分中药国家重点实验室、方剂学教育部重点实验室、天津市中药药理学重点实验室,天津 301617
- 折叠
摘要
静脉溶栓和血管取栓受严格的时间窗限制,且由于随后的血管再闭塞或"无复流"现象,大部分患者仍然需要通过自身代偿机制使缺血组织获得再灌注.良好的侧支循环能够延长治疗时间窗、增加脑组织对缺血缺氧的耐受、改善预后,促进侧支循环建立改善缺血组织的血流灌注成为治疗缺血性脑卒中的新思路.本文对侧支循环评估方法 、治疗方法 及临床意义等相关研究进行综述,为缺血性脑卒中的治疗提供指导.
Abstract
Intravenous thrombolysis and revascularisation are subject to strict time windows,and most patients still need to reperfuse ischaemic tissue through their own compensatory mechanisms due to subsequent re-occlusion or"no-reflow".A good collateral circulation can prolong the therapeutic window,increase the tolerance of brain tissue to ischaemia and hypoxia,and improve the prognosis,so promoting the establishment of collateral circulation to improve ischaemic tissue perfusion is a new idea in the treatment of ischaemic stroke.In this paper,we provides a review of relevant studies on methods of assessment of collateral circulation,therapeutic approaches,and clinical significance to provide guidance for the treatment of ischaemic stroke.
关键词
缺血性脑卒中/侧支循环/临床意义/治疗方法Key words
ischemic stroke/collateral circulation/clinical significance/treatment引用本文复制引用
基金项目
国家自然科学基金(81573644)
天津市自然科学基金(21JCYBJC01260)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据