Research status of kidney protection by proline hydroxylase inhibitors
Targeted regulation of hypoxia inducible factor(HIF)pathway can provide therapeutic basis for inflammatory anemia,hypoxic nephropathy,cardiovascular diseases related to chronic kidney disease and other hypoxic diseases.At present,the first drug to act on the HIF pathway,roxadustat,has been used for the treatment of renal anemia,and other prolyl hydroxylase(PHD)inhibitors are also in clinical research.This article mainly reviews the various pathways and mechanisms of the protective effect of PHD inhibitors on the kidneys.
prolyl hydroxylase inhibitorhypoxia inducible factorkidney protectionmechanism of action
国家科技期刊平台
NSTL
万方数据
维普
