靶向MDSCs免疫治疗结肠炎相关性癌症的研究现状
Research status in immunotherapy of colitis-related cancer with MDSCs
陈佳 1夏琪 2何钰洁 1李悦 2袁泽婷 2殷佩浩2
作者信息
- 1. 成都中医药大学医学与生命科学学院,四川成都 610075
- 2. 上海中医药大学附属普陀医院中西医结合肿瘤介入研究所,上海 200062
- 折叠
摘要
结肠炎相关性癌症(CAC)是一种特定类型的结直肠癌,由炎症性肠病(IBD)发展而来.髓源性抑制细胞(MDSCs)是一群具有免疫抑制性的髓细胞,肿瘤微环境中的MDSCs在结肠炎相关性癌症的发生发展过程中增殖、激活,抑制T细胞的生成并损害其功能,阻碍结肠炎相关性癌症的免疫治疗效果.本文就MDSCs在炎症性肠病到结肠炎相关性癌症的发生发展过程中的免疫抑制机制,以及目前靶向MDSCs免疫治疗炎症性结直肠癌的药物做一综述,以期为治疗结肠炎相关性癌症提供新的策略.
Abstract
Colitis-associated cancer(CAC)is a specific type of colorectal cancer that develops from inflammatory bowel disease(IBD).Myeloid-derived suppressor cells(MDSCs)are a group of myeloid cells with immunosuppressive properties,and MDSCs in the tumor microenvironment proliferate and activate during the development of colitis-associated cancer,inhibiting T-cell production and impairing their function,which impedes the immunotherapeutic effect of colitis-associated cancer.In this paper,we review the immunosuppressive mechanisms of MDSCs in the development of inflammatory bowel disease to colitis-associated cancers and the current drugs targeting MDSCs for immunotherapy of inflammatory colorectal cancers,with a view to providing new strategies for the treatment of colitis-associated cancers.
关键词
结肠炎相关性癌症/髓源性抑制细胞/免疫治疗Key words
colitis-related cancer/myeloid-derived suppressor cells/immunotherapy引用本文复制引用
基金项目
上海市普陀区卫生健康系统临床特色专科建设项目(2021tszk01)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据