胃食管反流病与慢性阻塞性肺疾病:两样本孟德尔随机化研究
Gastroesophageal reflux disease and chronic obstructive pulmonary disease:Two samples Mendelian randomization study
张露 1郭娜 1郭鸿 2刘健3
作者信息
- 1. 兰州大学第一临床医学院,甘肃兰州 730000
- 2. 兰州大学第一医院重症医学科,甘肃兰州 730000
- 3. 兰州大学第一临床医学院,甘肃兰州 730000;甘肃省妇幼保健院、甘肃省中心医院重症医学科,甘肃兰州 730000
- 折叠
摘要
目的 通过两样本孟德尔随机化方法,探讨胃食管反流病(GERD)和慢性阻塞性肺疾病(COPD)之间的因果关系.方法 从全基因组关联研究(GWAS)汇总数据中筛选出与GERD相关的单核苷酸多态性(SNP)作为基因工具变量,主要分析采用逆方差加权法(IVW)来估计因果效应,用MR-Egger、加权中位数法、simple mode法和weighted mode法作为补充方法.为评估结果的稳健性,进行了敏感性分析,包括Cochran's Q检验、MR-Egger截距和留一法.结果 GERD可能与COPD风险增加有关[IVW:优势比(OR)=1.80,95％置信区间(confidence interval,CI)为 1.55～2.08,P＜0.01].此外,MR-Egger 截距、Cochran'sQ检验及留一法未观察到水平多效性和异质性.结论 GERD可增加COPD风险,建议积极控制GERD以降低COPD的发生.
Abstract
Objective To explore the causal relationship between gastro esophageal reflux disease(GERD)and chronic obstructive pulmonary disease(COPD)by a two-sample Mendelian randomization method.Methods From the summary data of genome-wide association studies(GWAS),single nucleotide polymorphisms(SNP)associated with GERD were selected as genetic instrumental variables.The primary analysis employed the inverse variance weighted(IVW)method for estimating causal effects,with MR-Egger,weighted median,simple mode,and weighted mode methods as supplementary approaches.Sensitivity analyses were conducted to assess the robustness of the results,including Cochran's Q test,MR-Egger intercept,and leave-one-out analysis.Results There might be an association between GERD and an increased risk of COPD[IVW:odds ratio(OR)=1.80,95％confidence interval(CI)1.55-2.08,P＜0.01].Furthermore,no evidence of horizontal pleiotropy and heterogeneity was observed through MR-Egger intercept,Cochran's Q test,and leave-one-out analysis.Conclusion GERD can increase the risk of COPD,and aggressive control of GERD is recommended to reduce the incidence of COPD.
关键词
胃反流性食管炎/慢性阻塞性肺疾病/孟德尔随机化研究Key words
gastroesophageal reflux disease/chronic obstructive pulmonary disease/Mendelian randomization study引用本文复制引用
基金项目
甘肃省自然科学基金资助项目(20YF8FA082)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据